Author Archives: SerayaMaouche

Most of Human Genome Nonfunctional

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“Up to 25 percent of the human genome is critical, while the rest has no function, according to a study published July 11 in Genome Biology and Evolution. The estimate, generated by looking at fertility rates and the expected frequency of deleterious mutations, contradicts a 2012 claim from a large international group called ENCODE, which estimated that 80 percent of the genome is functional.”

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10 Years of GWAS Discovery: Biology, Function, and Translation

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“Application of the experimental design of genome-wide association studies (GWASs) is now 10 years old (young), and here we review the remarkable range of discoveries it has facilitated in population and complex-trait genetics, the biology of diseases, and translation toward new therapeutics. We predict the likely discoveries in the next 10 years, when GWASs will be based on millions of samples with array data imputed to a large fully sequenced reference panel and on hundreds of thousands of samples with whole-genome sequencing data…

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Cybersecurity: The cold war online

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“The Internet is under attack, and not just by hackers, thieves and spies. As Alexander Klimburg reports in The Darkening Web, governments that insist on their own primacy are increasingly assaulting the idea of this digitized landscape as a transnational commons. Cyberspace is becoming a war zone in a new era of ideological combat..’

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